An erectile dysfunction treatment system comprising a base unit capable of interfacing with the human body, a frame unit, a vacuum cylinder unit, a cap assembly with distraction means, a yoke assembly capable of interfacing with a human penis, and at least one vacuum line attachment. Use of the system involves the user preparing and inserting the penis into the yoke assembly, securing the penis in the yoke assembly, securing the frame around the penis secured in the yoke assembly, moving the yoke assembly so as to apply a distractive force to the inserted and secured penis, applying a vacuum to the inserted and secured penis and allowing distractive force and vacuum to operate for a therapeutic amount of time. The erectile dysfunction treatment system may be used to treat disorders such as Peyronie's disease and other forms of erectile dysfunction and may be used to enhance penile length and girth.