Richard C. Boucher, Jr.,Wanda ONeal,Barbara Grubb,Marcus Mall
申请号：
US12823243
公开号：
US08952214B2
申请日:
2010.06.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter construct directs expression of the epithelial sodium channel β subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
