特異性結合人ＩＬ－１７Ａ的分離的單克隆抗體农业专利-农业专业知识服务系统

发明人:: ULITIN, ANDREYBORISOVICH,乌里京　安德列鲍里索维奇,烏裡京　安德列鮑裡索維奇,EVDOKIMOV, STANISLAVRUDOLFOVICH,叶夫多基莫夫　斯坦尼斯拉夫鲁道夫维奇,葉夫多基莫夫　斯坦尼斯拉夫魯道夫維奇,SOLOVIEV, VALERIYVLADIMIROVICH,索洛维耶夫　瓦列里弗拉基米洛维奇,索洛維耶夫　瓦列裡弗拉基米洛維奇,CHERNYH, YULIA,乌里京安德列鲍里索维奇,烏裡京安德列鮑裡索維奇,叶夫多基莫夫斯坦尼斯拉夫鲁道夫维奇,葉夫多基莫夫斯坦尼斯拉夫魯道夫維奇,索洛维耶夫瓦列里弗拉基米洛维奇,索洛維耶夫瓦列裡弗拉基米洛維奇

摘要：: The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.本發明涉及醫學領域，尤其是涉及抗人IL-17的單克隆抗體領域。更詳細地說，本發明屬於單克隆抗體IL-17А拮抗劑，其與IL-17抗原表位高親和力結合；本文的抗體在重鏈和輕鏈的高變區包含胺基酸取代。本發明的抗體可以是嵌合的、人源化的或人抗體或其抗原結合片段，而且可用作藥物用於治療自身免疫和炎症性紊亂或細胞增殖和發育異常。本發明還涉及所述抗體的生產方法。