The present invention generally relates to immunogenic composition comprising Bordetella sp. Adenylate cyclase toxin (CyaA) for use for treating Bordetella bronchiseptica infections in non-human animals.More particularly, the invention relates to immunogenic composition comprising Bordetella sp. Adenylate cyclase toxin (CyaA) vector for use for treating Bordetella bronchiseptica infections in non-human animals.The present invention also relate to an immunogenic composition comprising a Bordetella sp. adenylate cyclase toxin (CyaA) vector carrying at least one antigen of Bordetella bronchiseptica.