A surgical system comprising a surgical instrument, a first handle assembly (100) and a second handle assembly (200) is disclosed. The surgical instrument comprises a shaft assembly (400) defining a longitudinal axis, an end effector (500) disposed adjacent a distal portion of the shaft assembly, and a control rod (140) disposed at least partially within the shaft assembly and being disposed in mechanical cooperation with the end effector. Actuation of the control rod effects a function of the end effector. The first handle assembly is configured for selective mechanical engagement with the control rod. The first handle assembly includes a power source (110) associated therewith. The second handle assembly is configured for selective mechanical engagement with the control rod. The second handle assembly is manually operable and is free from association with a power source.