This invention relates generally to the apparatus and method using ozone purification medicine equipment, it is particularly directed to purify the system, method and apparatus of continuous positive pressure ventilation (CPAP) equipment.Described device has ozone compartment, ozone operating system and one or more distribution ozone to the ozone distribution circuit of continuous positive pressure ventilation equipment.Described device can also further comprise heater adapter unit, with the heating system in connection CPAP equipment while CPAP equipment of the ozone purification according to the present invention is distributed.