The Board of Trustees of the Leland Stanford Junior University
发明人:
Daria Mochly-Rosen,Xin Qi,Nir Qvit
申请号：
US14271301
公开号：
US09243232B2
申请日:
2014.05.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on dynamin- 1-related protein (Drp1) GTPase activity, binding of Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.
