An antibody that binds to the active form of human plasma calicrein and does not bind to human precalicrein, and in which the antibody is selected from the group consisting of (i) an antibody comprising a VQL sequence of EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYRGRDVRDVRDVRDVRWRDVRWRDVRRDVRWRDVRWRDVRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWRWG DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRF SGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIK； (Ii) an antibody comprising a VH sequence EVQLLESGGGLVQPGGS LRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGI TVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRTGIPRRDAFDIWG QGTMVTVSSASTKGPSVFPLAPSSKS and a VL sequence QDIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPNLLIYKASTLESG VPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIK； (Iii) an antibody comprising a VH sequence EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYLMTWVRQAPGKGLEWVSYISPSGGHTIY ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVARGIAARSRTSYFDYWGQGTLV TVSS and a VL sequence EIVLTQSPGTLSLSPGERATLSCRTSQFVNSNYLAWYQQKPGQAPRLLIYGASSRATGIP DRFSGSGSGTDFTLTISRLEPEDFAVYYCQQSSRTPWTFGQGTKVEIK； (Iv) an antibody comprising a VH sequence EVQLLESGGGLVQPGGSLRLSCAA SGFTFSHYLMTWVRQAPGKGLEWVSYISPSGGHTIYADSVKGRFTISRDNSKNTLY LQMNSLRAEDTAVYYCARVARGIAARSRTSYFDYWGQGTLVTVSSASTKGPSVFP LAPSSKS and a VL sequence QDIQMTQSPG TLSLSPGERATLSCRTSQFVNSNYLAWYQQTPGQAPRLLIYGASSRAT GIPDRFSGTGYGTDFTLTISRLEPEDYGTYYCQQSSRTPWTFGQGTRVEIK； (V) an antibody comprising a VH sequence EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYLMTWVRQAPGKGLEWVSYISPSGGHTIY ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVARGIAARSRTSYFDYWGQGTLV TVSS and a VL sequence EIVLTQSPGTLSLSPGERATLSCRTSQFVNSNYLAWYQQKPGQAPRLLIYGASSRATGIPDR FSGSGSGTDFTLTISRLEPEDFAVYYCQQSSRTPWTFGQGTKVEIK； (Vi) an antibody comprising a VH EVQLLESGGG LVQPGGSLRL SCAASGFTFS sequence 30 SRDNSKNTLY LQMNSLRAED HYLMTWVRQA PGKGLEWVSY ISPSGGHTIYADSVKGRFTI TAVYYCARVA RGIAARSRTS YFDYWGQGTLVTVSSASTKG PSVFPLAPSS KS and a VL sequence QDIQMTQSPS FLSASVGDRV TITCRASQGI SSYLAWYQQK PGKAPKLLIY
