#$%^&*AU2011218607B220131003.pdf#####Abstract The present invention is to directed to novel methods for making discrete polyethylene glycol (dPEG) compounds selectively and specifically to a predetermined number of ethylene oxide units. The dPEG compounds contain a wider range of utility to make useful homofunctional and heterofunctional; and branched species. These methods include reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date.