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Gene expressing a bifidobacterium surface-presented fusion protein
专利权人:
Toshiro Shirakawa;Sakura Yamamoto;Takane Katayama;Kosuke Shimamoto;Masanori Asada;Jun Wada;Yasunobu Kano
发明人:
Toshiro Shirakawa,Sakura Yamamoto,Takane Katayama,Jun Wada,Yasunobu Kano,Masanori Asada,Kosuke Shimamoto
申请号:
US13124178
公开号:
US08354113B2
申请日:
2010.09.17
申请国别(地区):
US
年份:
2013
代理人:
摘要:
According to the present invention, there is provided a means of expressing and displaying a protein on the cell surface of a bifidobacterium. In the gene for expressing a protein on the surface of a bifidobacterium of the present invention, a gene coding for a bifidobacterium-derived GNB/LNB substrate-binding membrane protein and a gene coding for the target protein or peptide are linked in this order from the 5′ end side. Thus, a bifidobacterium transformed by introducing the gene for expressing a protein on the surface of a bifidobacterium of the present invention expresses the target protein or peptide on the surface thereof. When the target protein or peptide is an antigen protein or an antigen peptide, the transformed bifidobacterium of the present invention is useful as an oral vaccine.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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