The present disclosure provides recombinant antigen binding regions and antibodies and functional fragments containing such antigen binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen related cell adhesion molecule 6 CD66c Non specific crossreacting antigen NCA NCA 50/90) and which do not significantly cross react with the closely related human CEACAM1 human CEACAM3 and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies. The antibodies accordingly can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies vectors containing the same pharmaceutical compositions and kits with instructions for use.
