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Oxidation; drugs; drugs; treatment; drugs; treatment; treatment; and use of polychlorinated dioxide; and polychlorinated dioxide; and polychlorinated dioxide; drugs; and polychlorinated and other diseases
专利权人:
REATA PHARMACEUTICALS INC
发明人:
ANDERSON ERIC,LIU XIAOFENG,DECKER ANDREA
申请号:
CL2014002886
公开号:
CL2014002886A1
申请日:
2014.10.24
申请国别(地区):
CL
年份:
2015
代理人:
摘要:
The present invention relates to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-l,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide and polymorphic forms and pharmaceutical compositions thereof for use in the treatment of cancer in combination with immunotherapy, for use in the treatment of conditions associated with oxidative stree caused by mitochondrial dysfunction and for use in the treatment of seizure disorders.N-((4AS, 6AR, 6BS, 8AR, 12AS, 14AR, 14BS)-11-CIANO-2, 2, 6A, 6B, 9, 9, 12A-HEPTAMETIL-10,14-DIOXO-1, 2, 3, 4, 4A, 5, 6, 6A, 6B, 7, 8, 8A, 9, 10, 12A, 14, 14A, 14B-OCTADECAHIDROPICEN-4A-IL)-2,2-DIFLUORO PROPANAMIDA; FORMAS POLIMÓRFICAS; COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE; Y SU USO EN EL TRATAMIENTO DE INFLAMACIÓN, ESTRÉS OXIDATIVO, HIPERPROLIFERACIÓN CELULAR, ENTRE OTROS.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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