Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease
Avigdor Shafferman,Anat Zvi,Naomi Ariel,John Fulkerson,Roaggai Sun,Rosemary Chang,Jerald C. Sadoff
申请号：
US12618037
公开号：
US08361482B2
申请日:
2009.11.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
