Protective clothing materials and related methods and garments are provided. In some embodiments, a protective clothing material may comprise a fibrous layer that serves as a barrier to certain fluids (e.g., bodily fluids, water) and microbes. The impermeability of the fibrous layer may be due, at least in part, to the structural uniformity and/or relatively small pore size of the fibrous layer. In some embodiments, the fibrous layer may have a relatively high air permeability that imparts beneficial properties (e.g., relatively high air flow, breathability) to the protective clothing material without adversely affecting its protection rating. In certain embodiments, the protective clothing material may also comprise one or more coarse nonwoven webs that impart beneficial properties (e.g., splash resistance) to the protective clothing material. The protective clothing materials, described herein, may be particularly useful for a wide variety of applications, including the formation of AAMI level 4 protective garments.
