Pharmaceutical combinations comprising a beta-3 adrenergic receptor agonist and a muscarinic receptor antagonist, and methods for their use are disclosed. Methods of using the pharmaceutical combinations for the treatment of one or more symptoms associated with overactive bladder, for example, frequency of urgency, nocturia, and urinary incontinence, are also disclosed.揭露包含一β-3腎上腺素受體激動劑及一毒蕈鹼性受體拮抗劑之藥學組合物,及其使用方法。亦揭露使用此等藥學組合物用於治療與膀胱過動症有關之一或多個症狀,例如,頻繁急迫性、夜尿,及尿失禁,之方法。