Michael D. Bentley,Xuan Zhao,Xiaoming Shen,William D. Battle, III
申请号：
US16590235
公开号：
US20200048412A1
申请日:
2019.10.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —；O-alkylene-O—；, -alkylene-O-alkylene-, -aryl-O—；, —；O-aryl-, (—；O-alkylene-)m, or (-alkylene-O—；)m linkage, wherein m is 1-10.
