Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate
Chen Jinling,Deaver Matthew S.,Holl Richard J.,Nuguru Kalyan
申请号：
NZ71713712
公开号：
NZ717137A
申请日:
2012.10.16
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Provided are solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate (telotristat)or a pharmaceutically acceptable salt thereof. In a preferred embodiment the dosage form is a tablet made from intragranular and extragranular components, wherein the intragranular components consist of the hippurate salt of telotristat, lactose anhydrous, hydroxyl propyl cellulose, croscarmellose sodium, magnesium stearate, and the extragranular components consist of lactose anhydrous, croscarmellose sodium, colloidal silicon dioxide, and magnesium stearate.
