YAO, WENQING,HE, CHUNHONG,ZHUO, JINCONG,XU, MEIZHONG,ZHANG, COLIN,QIAN, DING-QUAN,BURNS, DAVID,METCALF, BRIAN W.
申请号：
ES05818772
公开号：
ES2547724T3
申请日:
2005.11.09
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: Cy is aryl or heteroaryl, each optionally substituted by 1, 2, 3, 4 or 5-W-X-Y-Z； Each -WXYZ is independently halo, CN, NO2, C1-4 alkoxy, heteroaryloxy, C2-6 alkynyl, C1-4 haloalkoxy, NRc C (O) Rd, NRcC (O) ORa, C (O) NRcRd, NRcRd , NReS (O) 2Rb, C1-4 haloalkyl, C1-6 alkyl, heterocycloalkyl, aryl or heteroaryl, wherein each of said C1-6 alkyl, aryl or heteroaryl is optionally substituted by 1, 2 or 3 halo, C1 alkyl -6, C1-4 haloalkyl, CN, NO2, ORa, SRa, C (O) NRcRd, NRc C (O) Rd or COORa； L is (CR12R13) q1 and q1 is 0； Q is cyclohexyl substituted at position 4 with at least one -W'-X'-Y'-Z '； each -W-X'-Y'-Z 'is, independently, OH, C1-4 alkoxy, CN, C1-4 alkyl, -O-heteroaryl, - (C1-4 alkyl) -CN, COORa, C (O ) NRcRd or NRcC (O) ORa； E is ethylene； R4, R5, R6, R7, R8, R9, R10 and R11 are each H； R12 and R13 are each independently H, halo, C1-4 alkyl, C1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO2, ORa ', SRa', C (O) Rb ', C ( O) NRc'Rd ', C (O) ORa', OC (O) Rb ', OC (O) NRc'Rd', NRc'Rd ', NRc'C (O) Rd', NRc'C (O) ORa ', S (O) Rb', S (O) NRc'Rd ', S (O) 2Rb' or S (O) 2NRc'Rd '； Ra and Ra 'are each independently H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl, wherein said C1-6 alkyl, C1 haloalkyl -6, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl is optionally substituted by H, OH, amino, halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl； Rb and Rb 'are each independently H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylal
