The present invention relates to a composition, being used to promote immune includes Lactobacillus salivarius, lactobacillus plantarum, Lactobacillus brevis, leuconostoc lactis and hay bacillus. Composition improves the expression of the nitrous oxide of immunocyte and active oxygen species according to the present invention, improve the yield of the secretion of expression or immune-related cell factor and the antibody to the poison of the virosis increased about domestic animal, increase the number of intestinal beneficial bacterium and the weight for reducing immune organ is effectively, to be effectively therefore used as an immune booster.Copyright KIPO 2017