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תכשירים המכילים תצמידי נוגדן-תרופה ושיטות לייצורם
专利权人:
DAIICHI SANKYO COMPANY LIMITED
发明人:
申请号:
IL25655817
公开号:
IL256558D0
申请日:
2017.12.25
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
A method for producing an antibody-drug conjugate composition, comprising: (i)a step of reacting an antibody with a reducing agent in a buffer to reduce interchain disulfides, and (ii)a step of reacting drug linker intermediates with the antibody having thiol groups obtained in the step (i), wherein the reaction temperature in the step (i) is -10°C to 10°C, and the average number of bound drugs in the produced antibody-drug conjugate composition is 3.5 to 4.5, and the content of antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, in the produced antibody-drug conjugate composition is 50% or more; and an antibody-drug conjugate composition, wherein the content of antibody-drug conjugates wherein the average number of bound drugs is 3.5 to 4.5, and the content of antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, is 50% or more.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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