IVAX INTERNATIONAL GMBH;TEVA PHARMACEUTICALS USA, INC.;ZIMMERMANN, Anne;FRØSTRUP, Brian
发明人:
ZIMMERMANN, Anne,FRØSTRUP, Brian
申请号：
USUS2012/068582
公开号：
WO2013/086425A1
申请日:
2012.12.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A salt of Pridopidine, a drug substance treats of Huntington's disease, include pharmaceutically acceptable hydfobromide salt, pharmaceutical compositions comprising this salt, and uses of this salt as a drug substance. The salt compounds improve symptoms of psychosis, including schizo-phrenia and schizophreniform disorders as well as drug induced psychotic disorders, behavioral disorders usually first diagnosed in infancy, childhood, or adolescence as well as in impulse control disorders, and speech disorders such as stuttering may improve. Other psychotic disorders not characterized as schizophrenia, schizo affective syndromes as well as psychotic symptoms, delusions and hallucinations induced by other drugs may also improve. Disruptive behavior disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder and oppositional defiant disorder may also improve, and tic disorders such as Gilles de la Tourette' s syndrome. Salt compounds may be used for treating substance abuse disorders as well as disorders characterized by misuse of food.Cette invention concerne un sel de pridopidine pour traiter la maladie de Huntington, notamment un bromhydrate pharmaceutiquement acceptable, des compositions pharmaceutiques comprenant ce sel, et les utilisations de ce sel comme substance pharmacologique. Les composés à base de sels de l'invention atténuent les symptômes de la psychose, comme la schizophrénie et les troubles schizophréniformes, les troubles psychotiques d'origine médicamenteuse, et les troubles du comportement généralement diagnostiqués pendant la première enfance, pendant l'enfance ou l'adolescence, les troubles du contrôle des impulsions, et les troubles du langage comme le bégaiement. D'autres troubles psychotiques ne figurant pas dans la catégorie de la schizophrénie, du trouble schizo-affectif, des symptômes de la psychose, du délire et des hallucinations d'origine médicamenteuse peuvent également être améliorés. Les troubles du comportemen
