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Spiro-condensed cyclohexane derivatives as HSL inhibitors useful in the treatment of diabetes
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- ACKERMANN, JEAN,BRUGGER, STEPHAN,CONTE, AURELIA,HUNZIKER, DANIEL,NEIDHART, WERNER,NETTEKOVEN, MATTHIAS,SCHULZ-GASCH, TANJA,WERTHEIMER, STANLEY
- 申请号：
- ES10770764
- 公开号：
- ES2538005T3
- 申请日:
- 2010.10.12
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- Compound of formula (I): ** Formula ** in which: R 1 is alkyl, phenyl, phenylalkyl, pyridinyl, pyridinylalkyl, pyridazinyl, pyridazinylalkyl, pyrazolyl, pyrazylalkyl, imidazolyl, imidazolyl alkyl, triazolyl, triazolyl-alkyl-2,2-2,2-alkyl benzo [1,3] dioxolyl, substituted phenyl, substituted phenylalkyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridazinyl, substituted pyridazinylalkyl, substituted pyrazolyl, substituted pyrazylalkyl, substituted imidazolyl, substituted imidazolyl alkyl, substituted triazolyl, substituted triazolyl, substituted phenylalkyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridazinyl, substituted pyridazinylalkyl, substituted pyrazolyl, substituted pyrazylalkyl, substituted imidazolyl, substituted imidazolyl alkyl, substituted triazolyl and independently substituted from one to three substituted allogenic, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, halocycloalkyl, halocycloalkylalkyl, hydroxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, alcoxihaloalquilo, haloalkoxyalkyl, alkenyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylsulfonyloxy and alkylsulfonyloxy； R2 is alkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxyalkyl, oxetanilalcoxilalquilo, alquiloxetanilalcoxilalquilo, hydroxyalkyl, hidroxihalolaquilo, dihidroxihaloalquilo, alkoxyalkyl, alkoxyalkoxyalkyl, haloalkyl, haloalkoxyalkyl, haloalquilalcoxialquilo, alquilsufinilalquilo, alkylsulfanylalkyl, alkylsulfonylalkyl, alkylcarbonyl, alkenyl, hydroxyalkenyl, alkoxyalkenyl, alkynyl, hydroxyalkynyl, alkoxyalkynyl, carboxyalkyl, alkoxycarbonylalkyl, dialkylaminocarbonylalkyl, alkylaminocarbonylalkyl, oxopirrolidinilalquilo, oxopiperidinilalquilo, triazolyl, pyrazolyl, isoxazolyl, thiophenyl, phenoxyalkyl, piridíniloxialquilo, oxopiridinilalquilo, (hydroxy) (pyrazolyl) alkyl, pyrazolylalkyl, benzyloxy, phenyl, phenylalkyl, substituted cycloalkyl, subst
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
