Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists

• 收藏
• 分享

专利权人:

Sha Mi

发明人:

Sha Mi,Vincent Jung

申请号：

US12375117

公开号：

US08642040B2

申请日:

2007.07.24

申请国别(地区):

US

年份:

2014

代理人:

摘要：

This invention relates to methods for promoting myelination, neuronal survival, and oligodendrocyte differentiation and treating demyelination and dysmyelination disease by the administration of a TrkA antagonist. The invention also relates to methods of inhibiting or decreasing Sp35 expression by the use of a TrkA antagonist. Additionally, the invention relates generally to methods for blocking Sp35 and TrkA interaction and inhibiting or decreasing TrkA phosphorylation by the administration of a Sp35 antagonist.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/