DIABETES T CELL RECEPTORS

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专利权人:

Neill MacKenzie

发明人:

Neill MacKenzie,Bent Jakobsen,Daniel Williams,Brian Cameron

申请号：

US13060230

公开号：

US20120027683A1

申请日:

2009.09.02

申请国别(地区):

US

年份:

2012

代理人:

摘要：

T cell receptors (TCRs) having the property of binding to a murine insulin-derived peptide, LYLVCGERG (SEQ ID NO:62), presented by the murine H-2Kd complex (LYLVCGERG-H-2Kd). The TCRs comprise at least one TCR α chain variable domain and/or at least one TCR β chain variable domain and have a KD for the LYLVCGERG-H-2Kd complex of less than or equal to 1 μM and/or have an off-rate (koff) for the LYLVCGERG-H-2Kd complex of 0.5 S−1 or slower, and use of such TCRs as research tools.

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