The Trustees of Columbia Univ. in the City of New York
发明人:
Samuel K. SIA,Brian M. GILLETTE
申请号：
US15325042
公开号：
US20170191035A1
申请日:
2015.07.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided are methods, apparatus, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes, by administration to a subject of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues or brown adipose tissue directly converted from white adipose tissue. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue and direct browning of white adipose tissue in a bioreactor rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3D cell aggregates.
