Pharmaceutical compositions that extend the effect and duration of a Clostridial toxin active ingredient are described. The compositions can be liquid or solid compositions, and comprise a non-cross-linked hyaluronic acid or salt thereof as described in the application, a surfactant and an antioxidant. In some embodiments, the compositions comprise a surfactant selected from a poloxamer and a polysorbate； an antioxidant selected from methionine, N-acetyl cysteine, ethylenediaminetetraacetic acid and combinations thereof, and, optionally, a tonicity agent and/or a lyoprotector selected from, for example, trehalose, sucrose.
