ETAT FRANCAIS Représenté par le Délégué Général pour l'Armement;Laboratoire Français du Fractionnement et des Biotechnologies
发明人:
THULLIER, Philippe,BEHRENS, Christian
申请号：
ES08856851
公开号：
ES2649565T3
申请日:
2008.11.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Class G immunoglobulin (IgG) directed against the anthrax toxin protective antigen (PA), comprising: - a light chain variable region having an amino acid sequence represented by the sequence SEQ ID No. 1 or having a amino acid sequence represented by the sequence SEQ ID No. 1 and further comprising at least one mutation selected from: - none / A (1) in which an amino acid A has been added at position -4 of the sequence SEQ ID N 1, that is, immediately before the remainder No. -3 if it exists, and by default immediately before the remainder No. -2, and by default immediately before the remainder No. -1, and by default immediately before of the remainder No. -1 - none / I (2) in which an amino acid L has been added at position -3 of the sequence SEQ ID No. 1, either immediately before the remainder No. -2 if it exists, and of by default, immediately before the rest No. -1, and by default, immediately before of the remainder No. 1 - none / Q (3) in which an amino acid Q has been added at position -2 of the sequence SEQ ID No. 1, either immediately before the remainder No. -1 if it exists, and so predetermined, immediately before the remainder No. 1 - none / L (4) in which an amino acid L has been added at position -1 of the sequence SEQ ID No. 1, well immediately before the remainder No. 1 - Y / S, wherein amino acid Y at position 10 of the sequence SEQ ID No. 1 has been replaced by amino acid S-K / R, where amino acid K at position 14 of the sequence SEQ ID No. 1 it has been replaced by the amino acid R-H / R, in which the amino acid H at position 20 of the sequence SEQ ID No. 1 has been replaced by the amino acid R-L / V, in which the amino acid L in the Position 100 of the sequence SEQ ID No. 1 has been replaced by amino acid V - a heavy chain variable region having an amino acid sequence represented by the sequence SEQ ID No. 2, or which it has an amino acid sequence represented by the sequence SEQ ID N ° 2 and which also comprises at least one mutation selected fr
