DERIVATI BENZAMIDA ZA INHIBIRANJE AKTIVNOSTI ABL1, ABL2 I BCR-ABL1

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专利权人:

NOVARTIS AG

发明人:

DODD, STEPHANIE, KAY,FURET, PASCAL,GROTZFELD, ROBERT, MARTIN,JONES, DARRYL, BRYNLEY,MANLEY, PAUL,MARZINZIK, ANDREAS,PELLE, XAVIER, FRANCOIS, ANDRE,SALEM, BAHAA,SCHOEPFER, JOSEPH,JAHNKE, WOLFGANG

申请号：

RSP20180497

公开号：

RS57177B1

申请日:

2013.05.09

申请国别(地区):

RS

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention； capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

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