The present invention relates to a composition for preventing, treating or ameliorating TRPV1 (Transient Receptor Potential channel, Vanilloid subfamily member 1) -mediated disease, which comprises an extract of Lactuca raddeana as an active ingredient. The composition of the present invention is a composition which is extracted from a natural plant material and which has no side effects on the human body. The composition provides prevention, treatment or improvement of pain and inflammation.본 발명은 산씀바귀(Lactuca raddeana) 추출물을 유효성분으로 포함하는 TRPV1(Transient Receptor Potential channel, Vanilloid subfamily member 1)-매개 질환의 예방, 치료 또는 개선용 조성물에 관한 것이다. 본 발명의 조성물은 천연 식물재료인 산씀바귀로부터 추출한 조성물로써 인체에 부작용이 없는 조성물이고, 상기 조성물은 통증 및 염증의 예방, 치료 또는 개선 효과를 제공한다.
