Non-toxic mucosal adjuvant

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专利权人:

ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル

发明人:

リノ ラポーリ

申请号：

JP2009221669

公开号：

JP5148577B2

申请日:

2009.09.25

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

<；P>；PROBLEM TO BE SOLVED: To provide an active mucosal adjuvant which can be used for increasing the immunogenicity of antigens when it is administered orally or at intranasal mucosal surfaces. <；P>；SOLUTION: There is provided a pharmaceutical composition comprising a nontoxic mucosal adjuvant mixed with a second antigen. In one embodiment, the composition comprises the nontoxic mucosal adjuvant which is a detoxified mutant of a bacterial ADP-ribosylated toxin and in another embodiment, comprises a mutant which is the detoxified mutant of CT or LT. <；P>；COPYRIGHT: (C)2010,JPO&INPIT

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