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POLYTHERAPIE OPTIMISEE ET SON UTILISATION POUR LE TRAITEMENT DU CANCER ET DE MALADIES AUTO-IMMUNES
专利权人:
LTD.;ZHEJIANG DTRM BIOPHARMA CO.
发明人:
HE, WEI
申请号:
CA2980016
公开号:
CA2980016A1
申请日:
2016.03.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Provided is a series of new poly-fluorosubstituted pyrazolopyrimidine compounds or salts. The compounds are Bruton's tyrosine kinase (BTK) inhibitors. The compounds have better kinase inhibition selectivity and pharmokinetic properties. Also provided is a preparation method for the compounds. Also provided is a combination therapy including the compounds in combination with another targeted drug composition or another drug. The optimised combination therapy has a cooperative effect, inhibits the existence of a tumour better than a single targeted drug, and causes certain tumours to completely disappear. The optimised combination therapy treats drug resistance and cancer recurrence of a tumour better than a single targeted drug, and the treatment cycle is shorter. The present invention also relates to a combined compound and a pharmaceutical preparation wherein said combined compound acts as an active ingredient, said pharmaceutical preparation being safer at a lower dosage and having a cooperative effect efficacy. Also provided is a method of using the compounds and a preparation thereof to treat and inhibit an autoimmune disease or illness, a heterogeneous autoimmune disease or illness, an inflammatory disease, a cancer or an illness.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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