CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATIONFOUNDATION;중앙대학교 산학협력단;CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION
发明人:
HAM, SEUNG WOOK,함승욱
申请号：
KR1020100079737
公开号：
KR1020120017196A
申请日:
2010.08.18
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A novel 2-aminothiazole derivative and an anticancer composition containing the same are provided to suppress growth and proliferation of various cancer cells and to induce cancer cell apoptosis. CONSTITUTION: A 2-aminothiazole derivative is denoted by chemical formula 1. In chemical formula 1, R1 is phenyl, halogen-substituted phenyl, alkyl of 1-4 carbon atoms, or phenyl-substituted alkyl of C1-4； and R2 is alkyl of C1-9, furyl-substituted alkyl of C1-4, furyl-substituted alkenyl of C1-4. An anticancer composition contains the 2-aminothiazole derivative of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The anticancer composition is a pharmaceutical composition for preventing or treating cancer.본 발명은 신규한 2-아미노티아졸 유도체 및 이의 항암 용도에 관한 것이다. 본 발명의 2-아미노티아졸 유도체는 다양한 암세포의 성장과 증식을 억제하며, 이러한 항암 활성은 암세포에서 카스파아제-3 활성화를 통한 아폽토시스(apoptosis, 세포사멸)를 유도하고, 암세포를 세포주기의 G1-기(G1-phase)에 중지(arrest)시키는 기작을 통해 달성된다. 본 발명의 2-아미노티아졸 유도체는 항암 약물로 매우 유용하게 개발될 수 있다.
