Changjiang PAN,Tao LIU,Tao GONG,Lincai ZHANG,Wei YE
申请号：
US15768904
公开号：
US20200254151A1
申请日:
2017.05.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method for preparing a chitosan/heparinized graphene oxide composite multilayer film on the surface of a medical magnesium alloy comprises the following steps: firstly preparing negatively charged heparinized graphene oxide； then performing surface chemical treatment and self-assembly of 16-phosphonohexadecanoic acid molecules on the medical magnesium alloy； further covalently immobilizing chitosan on the surface of the magnesium alloy, thereby constructing a positively charged material surface； finally, alternately immersing the surface-modified magnesium alloy material in heparinized graphene oxide and a chitosan solution, and then fully adsorbing, and obtaining the chitosan/heparinized graphene oxide composite multilayer film after drying. The surface modification of the medical magnesium alloy by adopting the method of the present invention can significantly improve the corrosion resistance and biocompatibility of the magnesium alloy to lay a foundation for the application of the magnesium alloy in the field of implantable medical devices such as vascular stents.
