PROBLEM TO BE SOLVED: To provide a technique for stimulating immunity of mammals.SOLUTION: RNA that consists of a base sequence shown by sequence number 1 below, and double-stranded RNA made up of RNA that consists of a base sequence shown by sequence number 2 below. It is to be noted that each base in a (N)12 portion in the base sequence shown by the sequence number 1 and the base sequence shown by the sequence number 2 may be complementary or may not be complementary, and all bases in a (N)5-10 portion in the base sequence shown by the sequence number 1 and the base sequence shown by the sequence number 2 are complementary bases, and a Tm value of the (N)5-10 portion is 20°C or higher. Sequence number 1:5'-UUGUCAUAUGGACAAGUCCAAGACU(N)12(N)5-10-3', sequence number 2:5'-(N)5-10(N)12AGUCUUGGACUUGUCCAUAUGACAA-3'.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2020,JPO&INPIT【課題】哺乳動物の免疫を賦活する技術の提供。【解決手段】下記配列番号１で表される塩基配列からなるＲＮＡ、及び、下記配列番号２で表される塩基配列からなるＲＮＡからなる二本鎖ＲＮＡ。ただし、前記配列番号１で表される塩基配列と前記配列番号２で表される塩基配列とにおける（Ｎ）１２部分の各塩基は相補的であっても相補的でなくてもよく、前記配列番号１で表される塩基配列と前記配列番号２で表される塩基配列とにおける（Ｎ）５－１０部分の各塩基はすべて相補的な塩基であって、該（Ｎ）５－１０部分のＴｍ値は２０℃以上である。配列番号１：５’－ＵＵＧＵＣＡＵＡＵＧＧＡＣＡＡＧＵＣＣＡＡＧＡＣＵ（Ｎ）１２（Ｎ）５－１０－３’、配列番号２：５’－（Ｎ）５－１０（Ｎ）１２ＡＧＵＣＵＵＧＧＡＣＵＵＧＵＣＣＡＵＡＵＧＡＣＡＡ－３’【選択図】図２
