Stefanie Dimmeler,Andreas M. Zeiher,Angelika Bonauer,Carmen Urbich
申请号：
US13569786
公开号：
US20120322856A1
申请日:
2012.08.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.
