The present invention relates i.a. to an immunogenic composition comprising: a) a modified live H3 virus of swine influenza, and b) a modified live H1 virus of swine influenza. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by swine influenza virus in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.本發明尤其係關於一種免疫原性組合物,其包括:a)豬流感之經改質活的H3病毒,及b)豬流感之經改質活的H1病毒。此外,本發明係關於對個體實施免疫之方法,其包括向該個體投與本發明之該免疫原性組合物。此外,本發明係關於治療或預防有需要之個體中由豬流感病毒引起之臨床體徵之方法,該方法包括向該個體投與治療有效量之本發明之免疫原性組合物。