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溶出率向上と副作用発現が最小化されたシルロスタゾール徐放錠
专利权人:
コリア ユナイテッド ファーム,インク
发明人:
チョイ、ヨウン-ウーン,ミン、ビュン-ク,チョ、サン-ミン
申请号:
JP2014221590
公开号:
JP6078514B2
申请日:
2014.10.30
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide a slow-release tablet of cilostazol which is a pharmacologically active component efficacious in the suppression of blood platelet aggregation and the promotion of vascular relaxation by inhibiting phosphodiesterase types, and represented by the following formula and, more specifically, provided is a slow-release cilostazol tablet of which the elution time is extended such that it can be taken once a day for expediency of drug-taking, and which minimizes the occurrence of headache which is a side effect during the taking of cilostazol preparations of the prior art and therefore improves the convenience of drug-taking for women, the elderly and children.SOLUTION: Provided is a slow-release cilostazol tablet which exhibits a stable elution pattern without any variation in the percentage eluted depending on the pH in the stomach in addition to an effect whereby release of the drug is delayed, by using a release-controlling polymer consisting of a mixture of hydroxypropyl methyl cellulose and a carbomer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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