FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS;UNIFEI - UNIVERSIDADE FEDERAL DE ITAJUBÁ
发明人:
AMANDA DE CARVALHO PEREIRA MORAES,CÉSAR AUGUSTO RIBEIRO,DANIELA SACHS,MAURICIO FROTA SARAIVA,PEDRO AUGUSTO DE ANDRADE NOVAES
申请号：
BR102018014234
公开号：
BR102018014234A2
申请日:
2018.07.12
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
fluoroquinolones with antimicrobial activity, this patent application demonstrates the antimicrobial activity of sixteen new molecules belonging to the class of terpenic fluoroquinolones, against gram-positive and gram-negative bacteria. unpublished terpenic fluoroquinolones were obtained from commercial fluoroquinolones, ciprofloxacin, gatifloxacin, moxifloxacin and gemifloxacin. terpenic fluoroquinolones, so called the molecules subject to this invention, were synthesized from the condensation between terpenic bromides (farnesyl bromide, geranyl bromide,neryl bromide and prenyl bromide) with their commercial fluoroquinolones ciprofloxacin, gatifloxacin, moxifloxacin or gemifloxacin.fluoroquinolonas terpenicas inéditas com atividade antimicrobiana o presente pedido de patente demostra a atividade antimicrobiana de dezesseis moléculas inéditas pertencente a classe das fluoroquinolonas terpênicas, contra bactérias gram-positivas e gram-negativas. as fluoroquinolonas terpênicas inéditas foram obtidos a partir das fluoroquinolonas comerciais, ciprofloxacina, gatifloxacina, moxifloxacina e gemifloxacina. as fluoroquinolonas terpênicas assim denominado as moléculas objeto da presente invenção, foram sintetizadas a partir da condensação entre brometos terpênicos (brometo de farnesila, brometo de geranila, brometo de nerila e brometo de prenila) com as respectivas fluoroquinolonas comerciais ciprofloxacina, gatifloxacina, moxifloxacina ou gemifloxacina.
