Yong HUANG,Dominique P. BRIDON,Xuexiang ZHANG,Chien-Ming LI
申请号：
US15744485
公开号：
US20180207169A1
申请日:
2016.07.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods for reducing platinum drug-induced toxicity in a cell expressing Organic Cation Transporter 2 (OCT2), methods for reducing platinum drug-induced toxicity in a subject, methods for treating cancer, methods for increasing efficacy of platinum drug treatment in a subject, and pharmaceutical compositions are described. The described methods and compositions include an OCT2 inhibitor where the OCT2 inhibitor is buflomedil or a salt thereof, dolutegravir or a salt thereof contains an imidazole, or is miconazole or a salt thereof.
