PROBLEM TO BE SOLVED: To clarify relationship between levels of various cytokines/chemokines contained in breast milk and an onset of atopic dermatitis, and based on this, to provide a method for predicting an onset of infantile atopic dermatitis based on cytokine/chemokine values in breast milk and a diagnostic agent used therefor, and a composition for preventing the onset of infantile atopic dermatitis.SOLUTION: There is provided a method for determining a risk of an onset of atopic dermatitis of an infant including (1) measuring a concentration of an eotaxin in mature milk taken by the infant, and (2) correlating the concentration of the eotaxin measured in step (1) with the risk of the onset of atopic dermatitis of the infant. A diagnostic agent for determining a risk of an onset of infantile atopic dermatitis, the agent containing an anti-human eotaxin antibody, and a composition for reducing the risk of the onset of infantile atopic dermatitis, the composition containing a compound for inhibiting production of an eotaxin are also provided.COPYRIGHT: (C)2014,JPO&INPIT【課題】母乳中に含まれる多様なサイトカイン/ケモカインのレベルと、アトピー性皮膚炎の発症との関連性を明らかにし、これに基づき、母乳中サイトカイン/ケモカイン値に基づく乳児アトピー性皮膚炎の発症予測方法及びそれに使用する診断薬、並びに乳児アトピー性皮膚炎の発症を予防するための組成物を提供すること。【解決手段】乳児のアトピー性皮膚炎の発症リスクを判定する方法であって、(1)当該乳児が摂取する成熟乳中のエオタキシンの濃度を測定すること、及び(2)(1)において測定したエオタキシンの濃度と、当該乳児のアトピー性皮膚炎の発症リスクとを相関付けることを含む、方法;抗ヒトエオタキシン抗体を含む乳児のアトピー性皮膚炎の発症リスクの判定用診断薬;エオタキシンの産生を阻害する化合物を含む、乳児のアトピー性皮膚炎の発症リスクを低減させる組成物。【選択図】なし
