John L. Magnani,Arun K. Sarkar,Myung-Gi Baek,Frank E. Anderson, III,Yanhong Li
申请号：
US14752056
公开号：
US09796745B2
申请日:
2015.06.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selection antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.
