Katharine ABBOTT-BANNER,John HANRAHAN,David THOMAS
申请号：
MX2016014756
公开号：
MX2016014756A
申请日:
2015.05.11
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The invention provides a compound for use in treating or preventing a disease or condition selected from cystic fibrosis, chronic obstructive pulmonary disease (COPD), asthma, mild pulmonary disease, bronchitis, bronchiectasis, idiopathic bronchiectasis, allergic bronchopulmonary aspergillosis, sinusitis, rhinosinusitis, CFTR-related metabolic syndrome (CRMS), pancreatitis, idiopathic chronic pancreatitis and Sjörgren's syndrome, or for use in preventing male infertility caused by congenital absence of the vas deferens, in a patient by modulating CFTR activity, which compound is 9,10-dimethoxy-2-(2,4,6- trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetr ahydro-2H-pyrimido[6,1- a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a composition comprising (i) 9,10-dimethoxy-2-(2,4,6- trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetr ahydro-2H-pyrimido[6,1- a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (ii) a leukotriene receptor antagonist. The invention also provides acomposition comprising (i) 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2- aminoethyl)-3,4,6,7- tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (ii) a CFTR potentiator or a CFTR corrector.La invención proporciona un compuesto para uso en el tratamiento o prevención de una enfermedad o afección seleccionada de fibrosis quística, enfermedad pulmonar obstructiva crónica (COPD), asma, enfermedad pulmonar leve, bronquitis, bronquiectasia, bronquiectasia idiopática, aspergilosis broncopulmonar alérgica, sinusitis, rinosinusitis, síndrome metabólico relacionado con CFTR (CRMS), pancreatitis, pancreatitis crónica idiopática y síndrome de Sjörgren, o para su uso en la prevención de la infertilidad masculina causada por la ausencia congénita de los conductos deferentes, en un paciente mediante la modulación de la
