USE OF HLA-B27 HOMODIMERS FOR CANCER TREATMENT

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专利权人:

发明人:

申请号：

EP16703507.0

公开号：

EP3253407A1

申请日:

2016.02.03

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The invention relates to a HLA-B27 Fc open conformer or a HLA-B27 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B27 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B27 Fc open conformer and immune checkpoint inhibitors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/