ANTI CXCR4 ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER

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专利权人:

发明人:

KLINGUER HAMOUR CHRISTINE,GRENIER CAUSSANEL VERONIQUE

申请号：

IN3042/DELNP/2011

公开号：

IN2011DN03042A

申请日:

2011.04.26

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. More particularly, the present invention relates to the 414H5 and 515H7 antibodies, specific to the CXCR4 protein, as well as then-use for the treatment of cancer. Pharmaceutical compositions composed of such antibodies and a process for the selection of such antibodies are also covered.

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