BIONTECH CELL & GENE THERAPIES GMBH;TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG
发明人:
Ugur SAHIN,Katharina REINHARD,Petra SIMON,Karolina Anna MROZ,Kathleen HOBOHM
申请号：
US15573045
公开号：
US20180140634A1
申请日:
2016.05.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
