Inc.;The Brigham and Women's Hospital, Inc.;The Brigham and Womens Hospital;Dana-Farber Cancer Institute, Inc.
发明人:
Kuchroo, Vijay K.,Monney, Laurent,Greenfield, Edward A.,Gaglia, Jason L.,Freeman, Gordon J.
申请号：
AU2009202143
公开号：
AU2009202143B2
申请日:
2009.05.29
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2009202143B220130221.pdf#####P: OPERNMKRISPEC2003303082dv doc-29/0r2009 ABSTRACT The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods 5 useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Thl cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.4/14 LN BRAIN 60~ 60z z 0 0 S40- 40 00 LU L >； 20-~ ~~ >； 20 Y -_ F . 0-0 DAY 0 7 10 16 DAY 0 10 13 16 SCORE 0 0 1 4.5 SCORE 0 0 1 3 4.5 Fig. 3A CD4+ CD8+ CD11b CD]9+ B220+ BRAIN * LN SPLEEN .. TIM-3 Fig. 3B
