The invention describes pharmaceutical, dietary and/or food compositions, preferably dietary supplements, exerting the ability to activate the endogenous antioxidant system by feeding essential micronutrients to both the one carbon cycle and the trans-sulfuration pathway so to achieve effective oxy-redox homeostasis together with an improved energy balance and healthy processes of cell growth and differentiation including DNA methylation and epigenetic regulation.The invention further relates to the use of the aforementioned compositions to decrease homocysteine levels and for the support to menopause, pregnancy and reproductive competence and for the prevention and/or treatment of diabetes, celiac disease, neurodegenerative diseases, cardiovascular diseases, Autism Spectrum Disorders (ASD) or Neurodevelopmental Disorders.
