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PHARMACEUTICAL COMPOSITIONS CONTAINING EPA AND CARDIOVASCULAR MEANS, AND WAYS OF THEIR APPLICATION
专利权人:
АМАРИН КОРПОРЕЙШН ПиЭлСи (IE)
发明人:
МАНКУ Мехар (GB),РОУ Джонатан (US)
申请号:
RU2013116807/15
公开号:
RU2013116807A
申请日:
2013.04.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating mixed dyslipidemia in an individual receiving a statin treatment, comprising administering to the individual 4 capsules, each of which contains approximately 1 g of ethyl eicosapentaenoate per day to reduce fasting triglycerides and LDL-C, in relation to individuals with mixed dyslipidemia who receive statin without the specified ethylacosapentaenoate. 2. The method according to claim 1, wherein the ethyl acosapentaenoate comprises at least 80% by weight of all the fatty acids present in the capsules. The method according to claim 1, wherein the ethyl acosapentaenoate comprises at least about 90%, by weight, of all the fatty acids present in the capsules. The method of claim 1, wherein the ethyl acosapentaenoate comprises at least about 95%, by weight, of all the fatty acids present in the capsules. The method according to any one of paragraphs. 1-4, in which the capsules comprise no more than about 20% docosahexaenoic acid or its esters, if any. The method of claim 5, wherein the capsules comprise no more than about 5% docosahexaenoic acid or its esters, if any. The method of claim 5, wherein the capsules comprise no more than about 3% docosahexaenoic acid or its esters, if any. The method of claim 1, wherein said step of administering reduces fasting triglycerides by at least 10% relative to individuals with mixed dyslipidemia who receive statin without said ethylacosapentaenoate. The method of claim 1, wherein said step of administering reduces fasting triglycerides by at least 15% relative to individuals with mixed dyslipidemia who are sexually1. Способ лечения смешанной дислипидемии у индивидуума, получающего лечение статином, включающий введение индивидууму 4 капсулы, каждая из которых содержит приблизительно 1 г этилэйкозапентаеноата в день для снижения триглицеридов и LDL-C натощак, по отношению к индивидуумам со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.2. Способ по п.1, в котором этилэйкоз
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