Device for the recovery of cell-free serum from whole blood, comprising a blood bag for the reception and the coagulation of the whole blood into a solid fraction and into a fluid containing a serum, wherein the blood bag has an outlet and a barrier in the area of the outlet which is suitable for retaining at least a major portion of the solid fraction and for the passage of said fluid, a filter module which is fluidically connected to the blood bag via the outlet, comprising an interior in which a semi-permeable membrane is arranged which subdivides the interior into a retentate space and a permeate space and allows the separation of the fluid into a serum as a permeate and into a retentate in which possible particulate components contained in the fluid remain, wherein the filter module has an inlet device for introducing the fluid into the retentate space and a permeate outlet for discharging the serum from the permeate space, and at least one receiving container for serum, comprising an inlet opening which is connected to the permeate outlet of the filter module via a connecting line.Method for the recovery of cell-free serum from whole blood, wherein the method can be carried out by means of the described device.