The present invention provides the dissolution improved pharmaceutical composition comprising olmesartan medoxomil and azelnidipine.The said pharmaceutical composition comprises (A) olmesartan medoxomil, (B) azelnidipin, and (c) polyvinylalcohol or vinyl alcohol-based copolymers.本發明提供含有奧美沙坦酯與阿折地平之溶出性經改善的醫藥組成物。此醫藥組成物含有(A)奧美沙坦酯、(B)阿折地平及(C)聚乙烯醇或乙烯醇系共聚物。